The strategy of buying healthy food
In order to eat, not necessarily radically change the place of purchase products. The following rules will help you to pursue the purchase of food necessary for healthy eating.

1. Pre-compiling a list of purchases. In order to shop, you need to know what and how much you need to buy. All purchased products must be itemized - something for breakfast, something for dinner, but something for dinner. A plan will make your shopping trip for products more efficiently and reduce the likelihood of accidental priobriteny.

In compiling the list of purchases are targeted to your diet and select products based on it.

It is desirable that in the purchases included: carrots, celery, apples, pears, oranges, fresh berries, grapes, lean cheese, yoghurt and other Low calorie.

2. When purchasing preference for fresh and processed products. When you buy semi loses control of the ingredients in them, which leads to consume excess quantities of fat and calories.

3. Hike to the shop on an empty stomach can lead to buying too fat and high in calories of food. If you really do have to go shopping hungry, then at least drink before entering the store water or Eat a little fruit.

4. Read the labels on products. Now almost any food you can find information about its composition and caloric content. These data will help you buy only the food that you need, and thus continue to adhere to a diet.

By CNN

Scientists disinfected mice from cirrhosis of the liver

Scientists from the University of California at San Diego proved: fibrosis of the liver can not just stop, but turn the process back. Their discovery opens the way for the development of new drugs against the virus, and alcoholic cirrhosis, pulmonary fibrosis, severe burns and the effects of scleroderma, said the journal PLoS Online.

When cirrhosis functioning healthy liver cells are gradually replaced by scar tissue, a process that until recently was considered to be irreversible. This disease kills 800 thousand people in the world.

In previous studies specialist at the University of California found a protein called RSK, plays an important role in the progression of fibrosis. Scientists under the leadership of Martina Buck went ahead and created substance, blocking the activity of protein RSK, as well as experienced its effect on mice with fibrosis (cirrhosis) liver.

In the first phase of mice injected with hepatic toxin, leading to the development of severe liver fibrosis. Then, one group of animals by adding peptide that blocks a protein RSK, with the introduction of toxin continued. The second group of animals received only the toxin.

«All the mice from the control group suffered severe liver fibrosis, while all the mice receiving RSK inhibitory peptide, had little fibrosis or does not suffer from liver fibrosis», - said Buck.

According to scientists, this peptide stopped the reproduction of liver cells generating excessive collagen by the action of free radicals. He also directly activated caspase - enzyme, destroying the cells responsible for the development of cirrhosis of the liver, but not affecting the normal cells. The peptide blocked the excess collagen education, not damaging the liver, said Buck.

Activation of protein RSK is not only animals but also in people with cirrhosis of the liver, which is why his blocking may be the basis for the development of new medicines against cirrhosis. According to scientists, this technique may also prove useful in fibrosis of the lungs, burns and the effects of some other process accompanied by excess formation of scar tissue.

High blood pressure is linked to dementia
Elderly people with high blood pressure may have problems in the development and training, which is one of the factors leading to dementia.

Hypertension is one of two types of moderate deterioration in the ability to learn. This may lead to a form of dementia is not associated with Alzheimer’s disease.

People with moderate deterioration in the ability to learn can have problems with speech, memory, attention and other mental functions, so significant that it is noticeable around and determined during the test.

Deterioration resulting from this syndrome, is not so strong as to interfere with privacy, no other symptoms other than as described above is not found.

The results of researchers from Columbia University (USA, New York) surveys show that people with high blood pressure often suffer deterioration in the ability to learn, which, in turn, could be precursor of vascular dementia (most common form of dementia after Alzheimer’s disease).

During a study conducted surveillance of 918 people aged under 76 years old, who had no problems with training at the start of data collection.

People who were under surveillance, were psychological tests and tests to assess learning at the beginning and end of the study (18 months). By the end of the study were 334 of the observed problems with training.

Summarizing the results of research statistics showed that people with hypertension for 40% more likely to suffer problems with training, which affect memory, and 70% more likely suffer the same problems, but that memory is not affected.

Earlier studies could not show until the end of the link between hypertension and dementia. These same data give an idea of how important the fight against hypertension in the future to ensure full health.

By Reuters

According to a study by scientists from Boston University (USA), for people affected by problems with weight, harder to deal with different kinds of infection.

In the words of Dr. S. Amara for many years, scientists could not find the mechanisms linking the deterioration of immunity and obesity. But recent experiments is to establish bacteria in the mouth normal mice and mice obese slightly expanded the knowledge of researchers in this field. Observations have shown that mouse over weight more seriously carry infection. They have some changes to the cellular level, which weakened immunity.

Final conclusions about the nature of these processes have been made, but the researchers suggest that obesity can lead to a change in the protein NF-kB, which is linked to the body’s immune response to infection.

Processes observed in mice, and may be repeated in humans. Proof of this is the statistics of gingivitis in people with normal body mass and increased weight.

Practical same conclusions were recommendations made by research scientists to conduct more aggressive anti-bacterial therapy in patients with excess weight.

Typically, stem cells belong to one of two types - embryo or adult. But this is too simplistic division - in the past few years, scientists realized that fetal stem cells to phenotype and functionally different from those and other and constitute a separate class. For example, fetal blood stem cells after transplantation of umbilical cord blood behave differently than adults donor blood cells.

Differences fetal stem cells, and confirms a new study, carried out at the University of Michigan. Scientists compared gene expression profiles of adult and fetal blood stem cells and identified a gene, Sox17, necessary for the functioning of blood stem cells from the developing mouse embryo and a newborn, but not in adult mice. This discovery sheds light on the mechanism underlying the differences between fetal and adult blood stem cells.

Study of these mechanisms can provide a deeper understanding of diseases such as childhood leukaemia. One of the following questions, which scientists intend to answer is whether, under certain childhood leukaemia occurring gene activation wrong Sox17. If so, this will bring new opportunities impact on the oncology process.

Shutting down Sox17 from mouse embryo or newborn mice resulted in serious violations of blood, including the lack of mature blood stem cells. At the blood of adult mice shutdown will not affect Sox17. It was found that the gene expression of hemopoietic stem cells are terminated in about 4 weeks after birth. During this transition gradual loss of Sox17 expression correlates with blood slowdown and the acquisition of hemopoietic stem cells adult phenotype. When irradiated mice transplanted fetal or neonatal stem cells with normally functioning gene Sox17, they restores blood; if the donor cells in Sox17 was switched off, not to restore blood.

Opening fetal blood regulating gene may also help to work on differentiation intended for transplanting blood stem cells from embryonic stem cells.

The study - part of the great work, which - to understand how stem cells work is regulated at different stages of the life cycle. Recently, this group of researchers reported that the aging of stem cells due not simply wear them actively “off” gene Ink4a.

Identification of each of the genes that control the operation of stem cells, gives them a deeper understanding of nature and allows management to move closer to their work, which gives new opportunities in cell therapy of various diseases.

Materials research presented in the article Kim I, Saunders TL, Morrison SJ. Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells. Cell. 2007 Jul 24; [Epub ahead of print]

According to Science Daily

Performed by scientists from the University of Nottingham study sheds light on the process of turning stem cells into cardiomyocytes. This work, funded by the biotechnology and biological research (Biotechnology and Biological Sciences Research Council (BBSRC)), provides an opportunity to develop new methods of cell therapy myocardial infarction.

Scientists have invented a new system to monitor in real time for cardiomyocytes differentiated into functioning stem cells. The registration changes characteristics of cells. This will provide more information on the electrical activity of cells of which are developing cardiomyocytes that in the future will make it possible to use these cells in regenerative therapy.

The new system for monitoring the developing cardiomyocytes will allow scientists to better understand their properties and needed to learn to grow the number of cell therapy cells. In addition, culture cardiomyocytes can be used for testing new medicines.

According to EurekAlert!

One of the most important conditions for the success of cell therapy lung damage is the choice of suitable time of transplantation. The team of scientists from the Beijing Institute of Basic Medical Sciences Chinese Academy of Medical Sciences has explored dependence trees and differentiation of stem cells (MSC) after transplantation into the lungs of time that has elapsed since no harmful effects.

The work was carried out on mice, whose lungs were subjected to radiation with intensity 1400 cGy. Then the mice were introduced Flk-1 (+) MSK of mice, genetically tagging green fluorescent protein. One group of animal cells injected systemically after 4 hours after exposure, the other - 60 days and third - 120 days.

Determines the degree of lung tissue fibrosis and participation in education MSK fibrous tissue. Ranked PCR method of expression in the lungs transforming growth factor beta1 (transforming growth factor (TGF)-beta1). In experiments in vitro MSK cultivated in epithelial differentiation inducing environment, along with damaged lung cells, supernatantom radiation from the damaged lung cells or TGF-beta1, to identify factors influencing the differentiation of MSK.

It was shown that MSK, imposed immediately after the injury, differentiated in the normal functioning epithelial and endothelial cells of the lungs. Introduced two months later MSK mostly localized in the interstitial area and look like miofibrotsity. Microenvironment in vivo in the light differently at different times after the injury, especially noticeable differences in expression of TGF-beta1. It was shown that in vitro allocated lung cells damaged by radiation cytokines inhibit differentiation Flk-1 (+) MSK in the epithelial cells.

Based on the results, scientists concluded that since differentiation Flk-1 (+) MSK controlled microenvironment, therapeutically justified immediately after transplantation MSK damaged lungs, because in this case differentiation occurs in the normal functioning lung cells. Introduction MSK after a long period of time after the injury leads to their participation in the development of fibrosis.

Materials research presented in the article Yan X, et al. Injured microenvironment directly guides the differentiation of engrafted Flk-1 (+) mesenchymal stem cell in lung. Exp Hematol. 2007 Jul 14; [Epub ahead of print]

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